ࡱ> egd'` RpPbjbj6j -$LLL8lL$/&H:"pppZ%\%\%\%\%\%\%$'h=*%i0@p%% Z% Z%  #V#< O ^L"#$%0/&*#,*q*V#*V#`pL6 ,ppp%%) dppp/&$$$d$$$$$$ u}Tyf[f[b,gyuRcؚyvyx~ WёP[i3u{|+R cWSyv% _>eyv% Ty(P[awSSOG2A(W@{Qv~ހ|DVP[h-Nvc:g6RxvzYe^YT ?bfWؚR xvzeT ~ހOSl[ T\Oc[Ye^ςgaOe _f_Ch bc6e,gyut^~TNpe 2008~,gyuW0W 5T xvzyvN~̀ofwƋ{Nb~Q[ 2003t^ LudwigI{(W Nature Bg_ N!kbS, OGR1uS]LvGˆ}vvPTSSO1 TGPR4Gˆ}vvPTSSO4 $N*NSSO:N(P[awSSOproton-sensing receptor KNT (Wf[/gLu_wNpR0(Wwwv1t^Q MurakamiTOkajimaSb?bfWؚR $N*Nxvz~R+RbSNG2ATTDAG8:N(P[awSSO0OGR1 G2A GPR4STDAG8Vy(P[awSSO/f^\NGˆ}vvPTSSO[eOGR1N[e [NKNwQ g40%~50%v^R Tn'` [N(WSOQe gTyr[v(RP[MSO S gqQ Tv(P[_Nyx'`pH MSO $NyN TvMSOGW;mS TN*NSSOTGvPTˆ}v FO/f g*b6qN TvR0xvzSs {|SSOdNTyck8^~~Y؏^lR^NNvTy$v~~~ހ-N N$vvSuNSU\0~ހg͑~0MQu|~T@{|~RI{ututǏ z g[RvsQ0s gxvzW@xbf[`NT]\OǏve,gl'Yf[RP[N~ހxvz@bOSl[xvz[Okajimaxvz[ (Wˆ}v@b+Tut;m'`(vSSOOSl[N~ހ:g uu`KNvsQ|T(P[awSSORW̑vxvzYNVEHQ4ls^0,gNN2001t^3geQZSXxvzu0Rs(W:Nbk NvN_RNˆ}vYHDL,LDLI{ @b+Tut;m'`(YS1P,LPA,LPCI{ vNNSSOOSl[:g6RN~ހ:g uu`YR lxS pu NSLvuS:gtI{ KNsQ|vxvz02003t^+g_YSR(P[awSSOSvQRvxvz (WbSTDAG8wang I{2004 JBC :N(P[awSSOvxvz~;NbXT0~SN9t^vxvz]\O q~vccNُNWvHQۏvxvzKbkTxvz`~ y/}N_YSYpencDe :NۏNekmeQc~0Wxvz wQYN_}YvW@x0(Wُg fSRǏYy v^r;NcNNye,gew :N ˆ}vNvQ\O(uvZNir ut;m'`( (WNLuCgZ'`f[/g Rirq_TVP[4N N NShY{e3uN{S 02006t^VVeQQS'Yf[u}Tyf[f[bT ck_zy^zN NxvzW:N,gf[y3z[vxvzeT v^]_Y/TR1 ˆ}v@b+Tut;m'`(YS1P,LPA,LPC vN"R`TSSON[OS_N~ހ:g0uu`YR lxS pu NSLvuS:gtI{ KNsQ|vxvz02 gNut;m'`(YSPC ,LPCI{ vSSOS/f(P[H+bpH SSO, ُN(T(P[(Wb[ TN*NSSO/fYUO\O(uv vQOSl[N~ހ:g uu`KNvsQ| gNuSMOYR lxS pu LvI{ vx'`S[~ހ:g gUO\O(uI{0]\xvzbgSh(W 0Am J Physiol 02007 T 0Vascular Pharmacol 02009 Bg_ N0SheNNW[1] Mayumi Komachi1Alatangaole Damirin1 Enkhzol MalchinkhuuChihiro MogiMasayuki ToboHideo OhtaKoichi SatoHideaki TomuraFumikazu Okajima: Signaling pathways involved in DNA synthesis and migration in response tolysophosphatidic acid and low-density lipoprotein in coronary artery smooth muscle cells Vascular Pharmacology 50 (2009)178 184 In press. v^O,{N\O NR1uV[6qyf[WёDRyvybS30760054 [2]Tomura, H., Wang, JQ., Liu., JP., Damirin, A., Komachi, Mogi, C., Tobo, M., Kon, J., Misawa, N., Sato, K., Okajima, F. Cyclooxygenase-2 Expression and Prostaglandin E(2) Production in Response to Acidic pH Through OGR1 in A Human Osteoblastic Cell Line.J Bone Miner Res. 2008 Feb 26 [q_TVP[5.3][3] HYPERLINK "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17237247&query_hl=1&itool=pubmed_docsum" Damirin A, Tomura H, Komachi M, Liu JP, Mogi C, Tobo M, Wang JQ, Kimura T, Kuwabara A, Yamazaki Y, Ohta H, Im DS, Sato K, Okajima F. Role of lipoprotein-associated l ysophospholipids in migratory activity of coronary artery smooth muscle cells.Am J Physiol Heart Circ Physiol. 2007 Jan 19 [q_TVP[4.0][4] HYPERLINK "http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17462861&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum" Tobo M, Tomura H, Mogi C, Wang JQ, Liu JP,, Damirin A, Komachi M Kimura T, Murata N, Kurose H, Sato K, Okajima F. Previously postulated "ligand-independent" signaling of GPR4 is mediated through proton-sensing mechanisms. Cell Signal. 2007 Mar 30; PMID: 17462861 [q_TVP[4.3][5]Damirin A, Tomura H, Komaci M, Tobo M, Sato K, Mogi C Nochi H Tamoto K, Okajima F Sphingosine-1-Phosphate Receptors Mediate the Lipid-Induced cAMP Accumulation Through Cyclooxygenase-2/Prostaglandin I2 Pathway in Human Coronary Artery Smooth Muscle Cells. Mol. 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(2005) [q_TVP[5.3][6]Tomura, H., Wang, JQ., Damirin, A.,Komachi, Mogi, C., Tobo, M., Kon, J., Misawa, N., Sato, K., Okajima, F. Prostaglandin I2 Production and cAMP Accumulation in Response to Acidic Extracellular pH Through OGR1 in Human Aortic Smooth Muscle Cells. J.Biol. Chem. 41: 34458-34464 (2005).[q_TVP[6.8][7] HYPERLINK "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17046831&query_hl=1&itool=pubmed_docsum" Kimura T, Tomura H, Mogi C, Kuwabara A, Damirin A, Ishizuka T, Sekiguchi A, Ishiwara M, Im DS, Sato K, Murakami M, Okajima F. Role of scavenger receptor class B type I and sphingosine 1-phosphate receptors in high density lipoprotein-induced inhibition of adhesion molecule expression in endothelial cells .J Biol Chem. 2006 Dec 8;281(49) [q_TVP[6.8][8]Mogi, C., Tomura, H., Tobo, M., Wang, JQ., Damirin A., Kon, J., Komachi, M., Hashimoto, K., Sato, K., and Okajima, F. (2005) Sphingosylphosphorylcholine Antagonizes Proton-Sensing OGR1-Mediated Inositol Phosphate Production and cAMP Accumulation. J. Pharmacol. Sci. 99: 160-167. [q_TVP[3.5][9]Wang, JQ., Kon, J., Tobo, M., Damirin, A., Sato, K., Komachi, M., Malchinkhuu, E., Murata, N., Kimura, T., Kuwabara, A., Wakamatsu, K., Koizumi, T., Uede, T., Tsujimoto, G., Kurose, H., Sato, T., Harada, A., Misawa, N., Tomura, H., and Okajima, F TDAG8 is a Proton- Sensing andPsychosine-Sensitive G-Protein-Coupled Receptor.J. Biol. Chem. . (2004)279: [q_TVP[6.8][10]Tamama, K, Tomura, H., Sato, K., Malchinkhuu, E., Damirin A., Kimura, T., Kuwabara, A., Murakami, M., Okajima. F. High-density lipoprotein inhibits migration of vascular smooth muscle cells through its sphingosine 1-phosphate component. Atherosclerosis 2005, 178 .[11]Ohta H, Sato K, Murata N, Damirin A, Malchinkhuu E, Kon J, Kimura T, Tobo M, Yamazaki Y, Watanabe T, Yagi M, Sato M, Suzuki R, Murooka H, Sakai T, Im D-S, Nochi H, Tamoto K, Tomura H and Okajima F. (2003) Ki16425, a subtype-selective antagonist for EDG- family lysophosphatidic acid receptors Mol. 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