ࡱ> molq` RlEbjbjqPqP6d::%8tbT;j"a;c;c;c;c;c;c;$d=h?;-;4;J$J$J$a;J$a;J$J$56 0 q]z!5:;0;5h@"h@(6h@6Ld6J$,;;#d;  u}Tyf[f[b,gyuRcؚyvyx~ WёP[i3u{|+R cWSyv% " _>eyv% Ty FAK [mTOROSv:g6Rxvz Ye^YT s_ xvzeT ~ހOSl[ T\Oc[Ye^ ?bfWؚR bc6e,gyut^~TNpe 06~2N007~3N008~3N xvzyvN~̀ofwƋ{Nb~Q[ mTOROSvR mTORthe mammalian target of rapamycin ˆ}vov^\NPIKKthe phosphatidylinositol kinase-related kinase [e \O:NSer/Throv w\O(u /fmTOROSv-N_OShV0mTOROSW,gR/faS%{QrQۏ c6R~ހu,яt^vxvz]\mTORNRirutTut0*NSOSNu $\vQ/f~ހuT|(WNw[1 2] mTORˆ}vov\O:N(WۏS NO[vOShV@wW,gvuirR]Ǐ z[3]0ǏWVredvelf(WredNmTORmTOR-/- v\ ڀ΀S0R5.5)YsS;n ڀ΀r^~ހ_Nb6R[4]0 TeredNS6K1S6K1-/- TS6K2S6K2-/- v\ b;ms>fWMNO[5] mTOR[Negڀ΀Tڀ΀r^~ހvuS/f_v[6]0[[%{QOSvaSTl[[NTsNRirڀ΀SuS[QuTuS%c@w͑v\O(u0(W^y~OS O[-N 'YǏmTORaS%{QTϑ4ls^ۏ c6Rۏߘ mTORC1@whQvϑs^a /f NN[ϑ4ls^v-N_aShV[7]0mTORSNaSeg%{Q0o }TLeptin(&v }by&vˆ}v)vOS:Ro_wSߘ[8]0;`KN mTOR@wN%{QvsQvutǏ z0mTOROSv~bN:g6R (WTsNRir-NmTORNvQ[N Tvˆ}v~T b_bN$NyYTSOmTORC1(mTOR Complex 1)TmTORC2(mTOR Complex 2)0WNǏSASQt^[mTORC1vxvz vMR:NmTOROSN[v:RoVP[;N gV{| sSuVP[T\ } %{QVP[ ϑSsX0]~c:yvN~ހ-NmTOROSvW,g~bSbTSC2/TSC1YTSO0Rheb0mTOR0S6K18h|SOˆ}vS6ovribosomal protein S6 kinases S6Ks T4EBP1the eIF4E-binding protein 1 4E-BP1 vQ-NTSC2/f͑vov ǏRhebmTORv;m'`0S6K1T4EBP1/fgwQyrrvmTOR N8nHe^hV [Nb_bN$Nags^LvmRNAlыvOS[9] ۏ ~ހvuTXk0VQRUYI{2004 !kbSNmTORSvQ^ir(WHeLa~ހv~ހhTgN Tev-Nvh`Q[10] OBh4tI{2007 bSN(uyr_'`b6RBRTRNAr^mmTORWV YtTvߘSLv~ހ-NmTORTS6K1v;m'`b6R[11]0s_I{2007 bSKQNQS}v~q\vmTORTS6K1WV[12] ُ/f~ހ-NmTOROSxvzv!kbS0FAKNmTOROSvsQ| FAKFocal adhesion kinase /fNy^SSOj(lxov [(W~ހy0~ހg͑cNS~ހX[;m-Nnbo@wQ['`v҉r0[SteT }0uVP[0:gh:Ro(urb)0ؚnSI{ހYV }o;m [13]03u(We,gQq\'Yf[v[Ss (WN$v~ހ-N(uFAKNIGF-IRvSRb6RBRTAE226Yt~ހT mTORvxxSS0Rb6R0 Te(uTAE226YtQS}v~q\΀?Qb~~~ހSs S6K1;m'`_NS0Rb6R0ُN~g:y@wFAKS/fmTORv N8nVP[0Peter T. JindraI{(W[MHC{|+R`!OSvxvz-NSs ;nFAKˆ}vvh mTORv Ser2448SrpS6vSer235/236vxxS4ls^S0RNf>f0Wb6R [14] 0FO/fFAK[mTOR:g6Rv^NnZi0Malike(W1996t^v[-NSs FAK(W1u~ހϞDeoSS6K1;m'`Ǐ z-Nnbo͑҉r FO:g6RNnZi[15]0GanI{2006 vxvzۏNekf (WFAKzSv293T~ހ-N S6K1T4EBP-1vxxSS0Rb6R0 (WredNTSC2v~ހ-N FAK[S6K1;m'`vRmdN[16]0ُN~g>f:yQFAKS/fTSC2v N8nVP[ [S6K1;m'`v/fǏTSC2[sv0vMRsQNmTOROSvR0~bTRP[:gtvxvz;N(WN0 v~ހ-N_U\ ~ހ-N gsQmTOROSvxvz؏*gbS0bNvMRg]\O]~fmTOROSX[(WNq\΀?Qb~~~ހ-Nv^T~ހu gsQ0(uFAKTIGF-IRvSRb6RBRTAE226Ytq\΀?Qb~~~ހ ‰[0R~ހuS0Rb6R FOdk~g؏Nnx[FAK[mTOROSvRP[:g6R0Vdk,gyvbǏ|~[ N~q\΀?Qb~~~ހTN293TT\ STO~ހ:NxvzPge NWVNˆ}v$NebeQKbfFAK[mTOROScvRP[:g6R0:NۏNekfmTOROS(Wq\ڀ΀r^~ހTegڀ΀vuS-Nv\O(u`Y[tNb/gW@x0Se.s[1] Shaw R J CantleyL C. Ras, PI3K and mTOR signalling controls tumour cell growth.Nature, 2006, 441:424-430.[2] Wullschleger S, Loewith R, Hall M N. TOR signaling in growth and metabolism.Cell, 2006, 124:471-484.[3] Schmelzle T, Hall M N. TOR, a central controller of cell growth. Cell, 2000, 103: 253-262.[4] Gangloff Y G, Mueller M, Dann S G, et al. Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development. Mol Cell Biol., 2004, 24(21):9508-9516.[5] Pende M, Um S H, Mieulet V, et al. S6K1-/-/S6K2-/- mice exhibit perinatal lethality and rapamycin-sensitive 5-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway. 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